drug interaction with haloperidol pharm mcq step 1?
A 62-year-old man is admitted to the hospital for treatment of a psychotic episode, for which he is given haloperidol. He is also being treated for electrolyte abnormalities, and is receiving salsalate therapy for treatment of osteoarthritis. While in the hospital, he complains of dizziness and tinnitus, and over the past 12-24 hours, he begins experiencing agitation, tachycardia, diaphoresis, and nausea with two episodes of vomiting. His signs and symptoms are most likely related to a drug interaction with one of his medications and which of the following?
A. Ammonium chloride
B. Calcium carbonate
C. Multivitamin
D. Sodium bicarbonate
E. Sodium lactate
i immediately thought d.
Filed under: Tinnitus Treatment
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I think you are correct, from what I think though, the drug interaction can be from the salsalate therapy interacting with the Ca Carb and Na Bicarb as well as the Na Lact, what makes you think specifically Na Bicarb.They all interfere with the renal excretion dependent on the pH.
Very difficult q, hope this helps, let me know how you go send me an email-I’ll be interested in it.
sodium bicarb is interacting with haloperidol be increasing the amount of drug in the blood. I believe by making it more soluable. your welcome